A Bibliometric Analysis of Research on Ketamine From 2001 to 2020.

Huihui Miao,Xiaowan Lin,Danyang Gao,Tianzuo Li,Kang Yu,Hui Qiao,Xiao Liu,Ying Cao

doi:10.3389/fnmol.2022.839198

Abstract

BackgroundKetamine is an intravenous anesthetic with analgesic effects that has a rapid onset and short duration of action. Many studies have been conducted on the use of ketamine; however, the quantity and quality of such studies have not been reported. Therefore, we aimed to conduct a bibliometric analysis of research on ketamine from 2001 to 2020.MethodsWe used the Web of Science database to get publications on ketamine from January 2001 to December 2020. Various bibliographic information was collected, including the number of publications, year of publication, country of origin, journal name, research hotspots, citation count, and author information.ResultsA total of 5,192 articles were included in the analysis. The United States published the highest number of papers on ketamine and the United States participated in publishing the most papers and disclosure funds. The types of articles in clinical trials were cited more frequently. Most articles on ketamine were published in the journal Anesthesia and Analgesia. Furthermore, the antidepressant effect of ketamine has been a research hotspot for the last 20 years.ConclusionThis study provided a comprehensive analysis of research on ketamine and highlighted the growing interest in ketamine and its antidepressant effects.

Highlights

Ketamine is a non-competitive ionized N-methyl-D-aspartate (NMDA) receptor antagonist
We analyzed the cooperation between countries for each published article (Figure 1B) and found that research cooperation was highest with the United States
We found that the top four cited papers were all related to the antidepressant effects of ketamine, and ten out of these twenty articles were on the antidepressant mechanism and clinical applications of ketamine (Table 6)

Summary

Introduction

Ketamine is a non-competitive ionized N-methyl-D-aspartate (NMDA) receptor antagonist. Ketamine could promote the endogenous opioid peptides release; affect the metabolism of monoamine neurotransmitters; stimulate μ, δ, and κ opioid receptors; and block Na+ and Ca2+ plasma channels to exert analgesic effects (Hirota and Lambert, 1996). The effects of ketamine are dose-dependent; in adults, the recovery period after the traditional clinical dose of ketamine for anesthesia is sometimes accompanied by a variety of adverse reactions, such as dreams and hallucinations. It has become one of the most commonly used basic drugs in pediatric clinical anesthesia because of Bibliometric Analysis on Ketamine its convenient route of administration and less respiratory depression; it is often used for pediatric anesthesia and perioperative analgesia. We aimed to conduct a bibliometric analysis of research on ketamine from 2001 to 2020

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Discussion

Conclusion