A bibliometric analysis of Research on Decellularized Matrix for Two Decades.

Abstract

The articles and reviews in the field of dECM from 2001 to 2021 were retrieved and extracted from the Web of Science Core Collection. The R package Bibliometrix, CiteSpace, VOSviewer and the online BIBLIOMETRC platform were utilized for bibliometric analysis, including specific characteristics of annual publications, influential countries/ regions, core journals, leading institutions, keywords, key references, co-cited authors, journals and institutions, cooperation and historical direct citations. Our study concluded core references that fueled the development of dECM and highlighted current research directions, hotpots and trends.From 2001 to 2021, 3,046 publications were retrieved in total, including 2700 articles and 349 reviews. The United States (n=895) produced the majority of publications, and the University of Pittsburgh (n=318) published most productions. Biomaterials were identified as the most productive and influential journal in the dECM field considering the number of publications (n=194), and total citations (n= 15,694). Immunomodulation, bioreactors, aging, 3d bioprinting, bone tissue engineering, bioink, hydrogel, biomaterials, and regeneration were the latest high-frequency keywords, indicating the emerging frontiers of dECM. In the field, decellularization techniques lay the foundation. Orthotopic transplantation of recellularized dECM and induction of specific cell differentiation promoted the bursts of research. 3D bioprinting and hydrogel based on dECM were extensively studied in recent years. The present study provided developmental trajectories, current research status, global collaboration patterns, hotpots, and trending topics of dECM. Decellularization techniques, tissue engineering to regenerate organs, and improvements in application are the major themes over the past two decades.