A bibliometric analysis of preclinical trials of Andrographis paniculata (Burm.f.) Nees in diabetes mellitus

Abstract

The prevalence of diabetes mellitus has increased over time. Medicinal plants, including Andrographis paniculata (Burm.f) Nees, are recognized for their use to manage hyperglycemia. Nowadays, plenty of papers are published about A. paniculata as an antidiabetic; however, no bibliometric study about the topic exists. This study examines the existing papers about the preclinical trial of A. paniculata as an antidiabetic agent using bibliometric analysis focusing on countries, institutions, publishers, authors, documents, and keywords. Bibliographic information of relevant research and conference articles were obtained from the Scopus database. In total, 97 articles published between 1994 and 2021 were selected, covering 376 authors and 1270 keywords. Data were analyzed bibliometrically using Vosviewer 1.6.16. A total of 97 published papers occurred from 1994 to 2021 were selected. India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology, and Agung Endro Nugroho (Universitas Gadjah Mada, Indonesia) were the most productive country, institution, publisher, and author, respectively. The analysis of the most influential papers, co-citation network of the most influential papers, bibliographical coupling network based on authors, and keyword co-occurrence network and overlay demonstrated that the abundance and variety of existing papers about preclinical trials of A. paniculata as an antidiabetic were from phytochemistry, pharmacology, and drug formulation. The findings of our analysis have implications for managerial and theoretical aspects on this topic, such as encouraging research collaborations by analyzing the contributions of countries, institutions, publishers, and authors and revealing research gaps (molecular mechanisms, toxicities and side effects, drug formulations, and clinical trials) to accept a phytomedicine as a therapeutic option. • The abundance of preclinical trials of Andrographis paniculata as antidiabetic. • India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology, and Agung Endro Nugroho were the most productive country, institution, publisher, and authors, respectively. • Research mapping is needed to determine the expansion of the research fields. • The related fields were phytochemistry, pharmacology, and drug formulation.