Abstract
BackgroundThe objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research. Folate receptor is expressed on a wide variety of cancers and certain immune cells.MethodsA Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2019). The following information was examined: publications per year, overall citations, top 10 authors, top 10 institutions, top 10 cited articles, top 10 countries, co-author collaborations and key areas of research.ResultsIn total, 3248 documents for folate receptor or folate binding protein were retrieved for the study years outlined in the methods section search query. The range was 1 per year in 1969 to 264 for the last full year studied (2018). A total of 123,720 citations for the 3248 documents retrieved represented a mean citation rate per article of 38.09 and range of 1667 citations (range 0 to 1667). Researchers in 71 countries authored publications analyzed in this study. The US was the leader in publications and had the highest ranking institution. The top 10 articles have been cited 7270 times during the time frame of this study. The top cited article had an average citation rate of 110 citations per year. Network maps revealed considerable co-authorship among several of the top 10 authors.ConclusionOur study presents several important insights into the features and impact of folate receptor research. To our knowledge, this is the first bibliometric analysis of folate receptor.
Highlights
The objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research
folate receptor (FR) is over-expressed at significant levels in cancer cells and immune cells where it mediates uptake of folate by receptormediated endocytosis [2, 7,8,9,10,11,12]
FR-α is upregulated in malignant tissues of epithelial origin such as ovarian carcinoma [19,20,21] while FR-β is overexpressed in certain subsets of macrophages [19]
Summary
The objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research. Folate receptor is expressed on a wide variety of cancers and certain immune cells. FR is over-expressed at significant levels in cancer cells and immune cells (e.g., macrophages) where it mediates uptake of folate by receptormediated endocytosis [2, 7,8,9,10,11,12]. Folate uptake occurs via the reduced folate carrier in virtually all cells of the body, only folate-linked conjugates can enter cells by means of the high affinity folate receptor [7,8,9,10,11,12,13]. FR-α is upregulated in malignant tissues of epithelial origin such as ovarian carcinoma [19,20,21] while FR-β is overexpressed in certain subsets of macrophages [19]
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