Abstract
Atopic dermatitis (AD) has been increasing in prevalence over the past few decades; however, AD has never been analyzed using a bibliometric approach. We searched for AD studies in the dermatology and allergy category of the Web of Science and SCOPUS databases using the keywords “atopic dermatitis”, “eczema”, and “atopy”. In total, 53,460 documents were retrieved. We analyzed annual publication trends and performed keyword and co-authorship network analyses. The annual number of AD publications has increased over the years. Asthma, food allergies, the skin barrier, IgE, and epidemiology have received extensive attention. The keywords ‘allergic rhinitis’, ‘child(ren)’, ‘quality of life’, and ‘probiotics’ have become more commonly used in recent years. AD research has been led by only a few countries, such as the USA, Germany, and the UK, and longstanding research topics such as asthma, allergy, and the immune system continue to be important. We suggest that global collaborations, research in developing countries, and research that is more holistic (thus exploring how genes, the immune system, the environment, and the microbiome together impact AD) are necessary.
Highlights
Introduction and Future PerspectivesHealthcareAtopic dermatitis (AD) is a chronic skin disease characterized by severe pruritus, recurrent eczema, sleep disruption, and skin manifestations
Five studies dealt with the microbiome [20,21,22,23,24] and the skin barrier [25,26,27,28,29]; three studies explored food allergies [30,31,32]; and two studies were epidemiological in nature [33,34]
The top five most frequently used keywords between 2010 and 2020 were ‘asthma’, ‘allergy’, ‘child(ren)’, ‘(allergic) rhinitis’, and ‘immunoglobulin E (IgE)’ (Figure 2D). These results suggest that asthma, allergy, IgE status, and childhood AD have been extensively and consistently studied over the past three decades, the occurrence ranking of IgE decreased over that time
Summary
Introduction and Future PerspectivesHealthcareAtopic dermatitis (AD) is a chronic skin disease characterized by severe pruritus, recurrent eczema, sleep disruption, and skin manifestations (erythema, edema, papulation, oozing and crusting, excoriation, lichenification, and dryness). AD reduces the quality of life [2], promotes suicidal ideation [3], and imposes significant economic burdens on patients and healthcare systems [4]. AD are hypersensitive to skin irritations, certain foods, and aero-allergens. They often develop other atopic disorders such as asthma or allergic rhinitis Developed drugs (dupilumab, oluminant, and rinvoq), a growing interest in patient quality of life, and new potential therapeutic targets (such as the gut and skin microbiomes [9,10,11,12,13,14]) have motivated researchers to intensify their current approaches and explore new areas of AD research
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