Abstract
Viticis Fructus (VF) was named Manjingzi as a commonly used traditional Chinese medicine (TCM) targeting various pains and inflammation for more than 2000 years. To guarantee the quality of Viticis Fructus, a simple, quick and eco-friendly Beta/ZSM-22 zeolites-based-mixed matrix solid-phase dispersion method (B/Z-MMSPD) was established for simultaneous extraction and determination of eight compounds (two phenolic acids, two iridoid glycosides, vanillin and three flavonoids) with different polarities from Viticis Fructus by high performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Beta and ZSM-22 were mixed as the sorbent. Water, tetrahydrofuran and methanol were blended with certain ratio as the eluent. Several parameters including types of sorbents, mass ratio of Beta to ZSM-22, mass ratio of matrix to sorbent, grinding time, types, concentration and volume of eluent were optimized. The recoveries of eight analytes were within the range of 95.0%–105% (RSDs ≤ 4.13%). The limits of detection and limits of quantitation ranged from 0.5 to 5.5 μg/g and from 1.5 to 16 μg/g, respectively. Compared to the traditional extract methods, it was a simple, rapid, efficient and green method. The results demonstrated that a simple, rapid, efficient and green B/Z-MMSPD was developed for the simultaneous extraction and determination of eight target analytes with different polarities for quality control of Viticis Fructus.
Highlights
Viticis Fructus (VF), the dried ripe fruit of Vitex trifolia L. var. simplicifolia Cham. or Vitex trifoliaL. (Verbenaceae), was named Manjingzi as one of commonly used traditional Chinese medicines (TCMs)
It was found that four analytes obtained the maximum extraction efficiency by Beta (40, SiO2 /Al2 O3 ratio) and another four analytes (p-hydroxybenzoic acid, luteolin, DHTMF and casticin) obtained the maximum extraction efficiency by ZSM-22 (70, SiO2 /Al2 O3 ratio)
It was found that four analytes obtained the maximum extraction efficiency by Beta (40, SiO2/Al2O3 ratio) and another four analytes (p-hydroxybenzoic acid, luteolin, DHTMF and casticin) obtained the Molecules 2019, 24, 3423 efficiency by ZSM-22 (70, SiO2/Al2O3 ratio)
Summary
L. (Verbenaceae), was named Manjingzi as one of commonly used traditional Chinese medicines (TCMs) It has been used as medicine for more than 2000 years in China. It was recorded in the Shennong Ben Cao Jing (Shennong’s Classic of Materia Medica) [1]. As documented in the Pharmacopoeia of the People’s Republic of China, VF could dispel wind-heat and improve mentality and vision. It has the effect of alleviating pyrexia, eyes and gums pain, giddiness and headache [4,5]
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