A Bayesian algorithm for sample size determination for equivalence and non-inferiority test

Abstract

Bayesian sample size estimation for equivalence and non-inferiority tests for diagnostic methods is considered. The goal of the study is to test whether a new screening test of interest is equivalent to, or not inferior to the reference test, which may or may not be a gold standard. Sample sizes are chosen by the model performance criteria of average posterior variance, length and coverage probability. In the absence of a gold standard, sample sizes are evaluated by the ratio of marginal probabilities of the two screening tests; whereas in the presence of gold standard, sample sizes are evaluated by the measures of sensitivity and specificity.