Abstract
Skin Biology Darker-skinned individuals have more melanin in their skin and a lower risk for skin cancers. The production of melanin in organelles called melanosomes is pH sensitive. Zhou et al. found that the enzymatic activity of soluble adenylyl cyclase (sAC) resulted in decreases in both melanosome pH and melanin synthesis. sAC deficiency or inhibitors increased melanosome pH and pigmentation in mice. This mechanism for rapidly regulating melanin synthesis could potentially be exploited to reduce skin cancer risk for fair-skinned individuals. Sci. Signal. 11 , eaau7987 (2018).
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