Abstract
AbstractA simple and efficient base‐ and metal‐ free protocol for the synthesis of 2‐aryl/heteroarylthiazoline from aryl/heteroaryl nitriles and cysteamine hydrochloride is reported. This method is applicable to a series of aryl/heteroaryl nitriles containing different substituents such as halides, amines, substituted azoles, etc. and furnishes the corresponding thiazolines in upto 99% yields. A selective synthesis of mono‐ or bis‐thiazoline in more than 90% yield was also observed by modifying the duration of the reaction. This novel methodology has been utilized for the synthesis of some important 2‐aryl/heteroarylthiazoline scaffolds which form a part of many biologically active molecules. A probable reaction mechanism involving the formation of highly activated arylimino chloride is also given.
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