Abstract

Infliximab is currently indicated for reducing signs and symptoms and inducing and maintaining clinical remission in patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy... and for reducing the number of draining enterocutaneous and rectovaginal fistulas and maintaining fistula closure in patients with fistulizing Crohn's disease. Drs. Lichtenstein and Loftus have debated the merits of lifelong therapy based on 1-yr outcomes of clinical trials in Crohn's disease, immunogenicity, safety, and health economics.

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