Abstract
This study aimed to isolate and diagnose the bacterial pathogens that causes pneumonia in sheep, study the biochemical and histopathological changes in lung tissue of infected animals and determining the most effective types of antibiotics for treating sheep diseased with pneumonia. 150 samples (50 nasal swabs, 50 tracheal samples, 50 lungs samples from slaughtered sheep) were collected randomly from different areas of Salah Aldeen governorate during the period (September 2019 till January 2020) .
 The results showed that no significant differences in the values between positive and negative results from nasal, tracheal and infected lungs at a probability level P< 0.05. And showed that Staphylococcus aureus and Klebsiella pneumonia are two main bacterial causes of pneumonia in sheep .
 In macroscopic examination the prominent lesion in most lung samples was congestion and presence of emphysema with an expansion of the bronchitis and found that the most common type of pneumonia infection is broncho pneumonia.
 All the isolated bacterial species; however, show sensitivity to the antibiotics chloramphenicol and trimethoprim + sulfamethoxazole except Pasteurella Spp., that it shows resistance to trimethoprim+ sulfamethoxazole.
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