Abstract
A DNA repair test was used in order to assess its applicability for detecting the genotoxicity of sunlight and of the light emitted by halogen lamps and fluorescent lamps. This experimental system compares the lethality of test agents in the Escherichia coli wild-type WP2 and its isogenic counterparts lacking, either individually or in combination, various DNA repair mechanisms. DNA repair-deficient strains included WP2uvrA (uvrA-), WP67 (uvrA- polA-), CM561 (lexA-), CM571 (recA-), WP100 (uvrA- recA-), and CM871 (uvrA- recA- lexA-). All light sources produced a substantial killing of repair-deficient strains, with a maximum activity in the triple mutant CM871, at doses that did not affect survival of the wild type. The genotoxicity of uncovered quartz halogen bulbs was particularly potent, compared to fluorescent lamps and sunlight. Moreover, the mechanisms involved in repairing the DNA damage induced by halogen lamps were similar to those of a 254 nm UV source. The spectrum of genetic damage produced by ...
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