Abstract
The title compound, 3,4,6,8,11-pentahydroxy-4-demethyl-1-triethylsiloxy-5,4-epoxymethanotaxen-12-one (C 26 H 44 O 8 Si), has been prepared in the search for new semi-synthetic analogues of taxol. It has been obtained from 2-debenzoyl-4,10-bisdeacetyl-7-triethylsilyl-baccatin III when treated in an alkaline or acidic medium. The structure was established as part of a contribution to the knowledge of structure-activity relationships. An intramolecular hydrogen bond is established between the hydroxyl groups HO13 and HO4. In addition, a hydrogen-bond network engaging all the hydroxyl groups of the molecule links the different molecules in the crystal
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