Abstract
The cellular and serum antibody response of normal hamsters to oral and parenteral immunization with BSA has been examined with a combined immunofluorescent and autoradiographic technique. This technique allowed the determination of the immunoglobulin class of specific antibody-containing cells in one cryostat section at the same time. A predominantly γA antibody response was seen in the lamina propria with both routes of immunization. The mesenteric lymph node and spleen possessed more γA antibody-containing cells after oral immunization than the parenteral route. Serum γA antibody was only detected on day 2 by radioimmunodiffusion. A phasic serum γM antibody response was found after oral immunization, with peaks on days 4 and 21. The available evidence suggests that the route of immunization and antigen distribution influences the commitment to γA antibody synthesis, and that extraintestinal γA synthesis may result from intestinal lymphoid tissue dissemination.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
