Abstract
Electron microscopic examination of the P- 3 mouse myeloma cell line revealed that most cells contained a very large number of intracisternal A-type particles, while only a few C-type particles appeared to be produced. The C-type particle was readily isolated in 3T 3 mouse fibroblast cells where its presence could be demonstrated both by the RIF test and by electron microscopy, which revealed numerous extracellular C-type particles, but no A-type particles. Since the P- 3 cells in contrast contained many more A-type than C-type particles, it is suggested that (1) intracisternal A-type particles are not precursors of C-type particles, (2) intracisternal A-type particles are not infectious.
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