Abstract
Background: Childhood leukemia is not a common disease. However, the most common malignant neoplasms in children are the leukemias, and 77% of these cases are acute lymphoblastic leukemia (ALL). Case Report: We report a case of precursor B-cell ALL, initially presented by unusual manifestations such as; teeth ache, loose teeth and gum swelling, knee pain and a normal cell blood count (CBC). It was first considered to be Histiocytosis. Several laboratory workups have been performed to rule out the immunologic, infectious and rheumatologic diseases. A bone marrow aspiration revealed the diagnosis of leukemia. However, acute myeloid leukemia is more famous for being accompanied by oral presentation; our patient was afflicted by ALL. The patient was first referred to a dentist for the oral manifestations. Conclusion: This case reminds the importance of systemic evaluation of localized signs and symptoms in children and detailed history taking, follow-ups and physical examination.[GMJ.2016;5(4):215-18]
Highlights
The most common malignant neoplasms in children are the leukemias, and 77% of these cases are acute lymphoblastic leukemia (ALL)
Gingival hyperplasia is commonly seen in acute leukemia which can be localized or generalized and caused by inflammation or leukemic infiltration
Gingival hyperplasia is mostly seen in AML, commonly in acute monocytic leukemia (M5) and acute myelocytic leukemia (M1, M2) [7]
Summary
The most common malignant neoplasms in children are the leukemias, and 77% of these cases are acute lymphoblastic leukemia (ALL). Oral manifestation in Leukemia he could just eat watery foods On physical examination, both sides of the left knee were found to be tender. Funduscopic retinal exam of both eyes and other neurologic examinations were unremarkable On oral exam, he had poor oral hygiene, several teeth decays, and swollen gum without bleeding, swollen upper lip and chin (more prominent on the left side) and a subcutaneous mass were palpated on the left maxilla beneath the eye. In about one month (until the end of the induction phase of the chemotherapy), the loose teeth improved, and he began to eat and chew the solid food. During the 2-year follow-up, he was completely well and in complete remission
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