A-79 Case Series Evaluating Quantitative Electroencephalograph and Neuropsychological Function in Neurological Lyme Disease

Abstract

Abstract Objectives The purpose of this study was to investigate the characteristics of physician diagnosed Neurological Lyme disease (NLD) using Quantitative EEG and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We hypothesize that findings would include more slow wave (Delta/Theta) activity that is consistent with the severity reported dysfunction. Methods Subjects consisted of four adult females with a physician provided diagnosis of NLD. EEG was recorded from 21 sites during an eyes open and eyes-closed resting conditions. Raw EEG data was made quantifiable (qEEG) through Fourier transformation to determine z-score derived cortical and subcortical slow wave activity. The RBANS was used to assess each subject’s functioning. Results (See Imaging). Subject 1. Theta: 3.7. Alpha: 2.3. Theta: 3.2. Alpha: 2.5. RBANS - 96. Subject 2. Theta: 1.9. Alpha: 3.1. Theta: 2.3. Alpha: 4.4. RBANS - 76. Subject 3. Theta: 3.4. Alpha: 2.8. Theta: 3.5. Alpha: 2.1. RBANS - 110. Subject 4. Theta: 3.6. Alpha: 3.0. Theta: 3.3. Alpha: 2.8. RBANS - 100. Conclusions NLD subjects within this study all demonstrated elevated subcortical frontal and frontotemporal theta and alpha. Elevation in cortical slow wave activity was found for subjects with greater reported symptomatology and may suggest either less severe course of disease or serve as a recovery marker. RBANS assessment variables were not completely sensitive in detection of subject reported challenges. Implications for conceptualization, treatment, and disease monitoring are highlighted. Directions for future research will also be discussed.