A 65-nm CMOS fully-integrated circulating tumor cell and exosome analyzer using an on-chip vector network analyzer and a transmission-line-based detection window

Abstract

A fully-integrated CMOS circuit based on a vector network analyzer (VNA) and a transmission-line-based detection window for circulating tumor cell (CTC) and exosome analysis is presented. We have introduced a fully-integrated architecture, which eliminates the undesired parasitic components and enables high-sensitivity, for analysis of extremely low-concentration CTC in blood. To validate the operation of the proposed system, a test chip was fabricated using 65-nm CMOS technology. Measurement results shows the effectiveness of the approach.