Abstract
Pagets disease (PD) of the bone is a chronic metabolic disorder involving increased bone turnover with abnormal repair, leading to bony deformities and associated pain. It is characterised by a disturbance in bone modelling and remodelling because of increased osteoclastic activity followed by improper osteoblastic repair. Although PD of bone is an uncommon entity, axial skeleton involving pelvic bones, spine and skull are the commonest sites. Here we report a case of 65-yearold postmenopausal female who presented with generalised bone pain and subsequently was diagnosed as a case of Pagets disease and managed accordingly.J Enam Med Col 2016; 6(2): 106-109
Highlights
Paget’s Disease (PD) of bone is relatively an uncommon entity in Asian nations especially India.[1,2,3]It is more prevalent in European nations and people of Anglo Saxon origin.[4]
PD of bone occurs in two forms, monostotic and polyostotic
At times sclerotic phase presents a radiological dilemma, as bone expansion conventionaly seen with PDB is not seen in a few cases, especially when PDB arises at areas known to be conventional sites for bony metastasis in breast and prostate cancer.[10]
Summary
Paget’s Disease (PD) of bone is relatively an uncommon entity in Asian nations especially India.[1,2,3] It is more prevalent in European nations and people of Anglo Saxon origin.[4] The overall prevalence of PD is 3 to 3.5% and this increases with age.[5] It is mostly seen in the middle aged and elderly, though ‘juvenile pagets’ is a known entity, where patients are usually less than forty years of age and have an aggressive clinical course.[6] Males are affected more than than females.[7] Many a times patients are asymptomatic[8] and the disease is incidentally picked up by radiologists or at a tertiary care centre, when patients are being evaluated for other diseases.[7] Clinical course of the disease is insidious and over a period of time patients develop symptoms of bone pain, facial deformity, fractures and other complications like hearing impairment and compressive myelopathy. Remission induction is assessed by symptomatic improvement and normalisation of markers like alkaline phosphatase.[9]
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