A - 58 Verbal Fluency Word Generation Slope among Older Adults with MS.

Abstract

The decreasing rate of within-person word generation in verbal fluency (VF) tasks, here referred to as slope, is associated with mild cognitive impairment and with lower grey matter volume in select regions. While VF is sensitive to cognitive decline in Multiple Sclerosis (MS), VF slopes have yet to be assessed in older adults with MS. We, therefore, examined VF slopes in letter and category VF among dementia-free older adults with and without MS. 84 community-dwelling adults with MS (Mage = 64.7) and 86 without MS (Mage = 70.8) completed standard 60-sec letter (F, A, S) and category (fruits, vegetables, animals) VF tasks; responses were recorded in 20-sec intervals for each iteration of the task. Linear regressions showed that MS was associated with lower total word generation on category, but not letter, VF after accounting for age, sex, race, education, and health status (95% CI, [-2.27, -0.98], p < 0.001). Linear mixed effects models showed that word generation declined during the course of both tasks (all p's < 0.001) in both groups; MS status did not moderate category or letter VF slopes. Extant literature on total letter and category VF word generation in MS is mixed. The current study indicates that in community-dwelling older adults MS was associated with lower total word scores in category but not letter VF. Negative word generation slopes were documented in category and letter VF irrespective of group status. These results suggest that time effects on word generation in VF tasks were generalizable to normal aging and MS.