A 4-minute solution for submillimeter whole-brain T1ρ quantification.

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To develop a robust, accurate, and accelerated T1ρ quantification solution for submillimeter in vivo whole-brain imaging. A multislice T1ρ mapping solution (MS-T1ρ ) was developed based on a two-acquisition scheme using turbo spin echo with RF cycling to allow for whole-brain coverage with 0.8-mm in-plane resolution. A compressed sensing-based fast imaging method, SCOPE, was used to accelerate the MS-T1ρ acquisition time to a total scan time of 3 minutes 31 seconds. A phantom experiment was conducted to assess the accuracy of MS-T1ρ by comparing the T1ρ value obtained using MS-T1ρ with the reference value obtained using the standard single-slice T1ρ mapping method. In vivo scans of 13 volunteers were acquired prospectively to validate the robustness of MS-T1ρ . In the phantom study, the T1ρ values obtained with MS-T1ρ were in good agreement with the reference T1ρ values (R2 = 0.9991) and showed high consistency throughout all slices (coefficient of variation = 2.2 ± 2.43%). In the in vivo experiments, T1ρ maps were successfully acquired for all volunteers with no visually noticeable artifacts. There was no significant difference in T1ρ values between MS-T1ρ acquisitions and fully sampled acquisitions for all brain tissues (p-value > .05). In the intraclass correlation coefficient and Bland-Altman analyses, the accelerated T1ρ measurements show moderate to good agreement to the fully sampled reference values. The proposed MS-T1ρ solution allows for high-resolution whole-brain T1ρ mapping within 4 minutes and may provide a potential tool for investigating neural diseases.