A 3D-Pharmacophore Model for Dopamine D4 Receptor Antagonists

Tommy Liljefors,Jonas Boström,Klaus Gundertofte

doi:10.1007/978-1-4615-4141-7_87

A 3D-Pharmacophore Model for Dopamine D4 Receptor Antagonists

Tommy Liljefors, Jonas Boström + Show 1 more

https://doi.org/10.1007/978-1-4615-4141-7_87

Copy DOI

Publication Date: Jan 1, 2000

Affiliation: Schools of Visual Arts, The Royal Danish Academy of Fine Arts, Lundbeck (Denmark)

#Selective Dopamine D4 Receptor Antagonists #Selective Dopamine D4 Receptor + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

Selective dopamine (DA) D4 receptor antagonists may be effective antipsychotics, without the extrapyramidal side effects which are well established for DA D2 antagonists. In order to facilitate the design of new selective DA D4 receptor antagonists we are currently developing a DA D4 3D-pharmacophore model. Previously, a 3D-pharmacophore model for DA D2 antagonists has been developedl. This model rationalizes the high affinity of both enantiomers of octoclothepin (1)2.

Full Text