Abstract
Abstract Background COVID-19 and influenza are highly contagious respiratory diseases and are sometimes fatal, making them a major concern worldwide. Hence, rapid and accurate detection and differentiation are required as preventive measures to control the further spread of these diseases. Methods We evaluated performance of the Standard Q COVID/FLU Ag Combo test (Q Ag combo test) (SD Biosensor, Korea) for detection of SARS-CoV-2, influenza A, or influenza B using a single point-of-care device compared with real-time PCR. A total of 408 individuals: 55 positives of SARS-CoV-2, 90 influenza A, 68 influenza B, and 195 negatives from all viruses investigated. Results The Q Ag combo test demonstrated a high sensitivity of up to 92.73% and specificity of up to 99.49% for the detection of SARS-CoV-2. Similarly, a sensitivity of 92.22% and specificity of 100% for influenza A, and a sensitivity of 91.18%, and a specificity of 99.49% for influenza B were observed. When the days from symptom onset (DSO) were restricted to 0<DSO≤6, the sensitivity of the Q Ag combo test to detect SARS-CoV-2 was up to 100%, and when the Ct value of RdRp is ≤ 20, the sensitivity to detect SARS-CoV-2 was up to 93.10%. Conclusion The Q Ag combo might be useful to detect and differentiate SARS-CoV-2, and influenza A/B efficiently and rapidly.
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