Abstract
BackgroundG-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. However, no report has described the effects of GNB1L indels on the chicken carcass and growth traits.ResultsThis study identified a 31-bp indel in the 5′ untranslated region (UTR) of GNB1L and elucidated the effect of this gene mutation on the carcass and growth traits in chickens. The 31-bp indel showed a highly significant association with the body weight at 8 different stages and was significantly correlated with daily gains at 0 to 4 weeks and 4 to 8 weeks. Similarly, the mutation was significantly associated with small intestine length, breast width, breast depth and breast muscle weight. Moreover, DD and ID were superior genotypes for chicken growth and carcass traits.ConclusionsThese results show that the 31-bp indel of GNB1L significantly affects chicken body weight and carcass traits and can serve as a candidate molecular marker for chicken genetics and breeding programs.
Highlights
G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide
We examined the distribution of the 31-bp indel in different populations. These results indicated that the 31-bp indel mutation in GNB1L could be used as a candidate molecular marker for chicken growth traits and provided a reference for the molecular breeding of chickens
Polymorphism detection and genotyping A novel 31-bp indel polymorphism in the 5′ untranslated region (UTR) region of GNB1L was observed by DNA sequencing (Figure S1) (TSINGKE, Guangzhou, China)
Summary
G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. No report has described the effects of GNB1L indels on the chicken carcass and growth traits. G-protein subunit beta 1 like (GNB1L) encodes a Gprotein beta-subunit-like polypeptide that lacks homology with known proteins [4]. In the study of chickens, the candidate gene GNB1L for the ear-tufted trait was verified by GWAS and haplotype analysis [8]. GNB1L was shown to be related to higher feed efficiency, it is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that of low feed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
