Abstract

Ultrasound cyclo plasty (UCP) is a recently developed surgical technique for glaucoma allowing a selective and controlled coagulation of the ciliary body. We herein investigated the long-term efficacy and safety of UCP for the treatment of glaucoma. This prospective study included patients with primary and secondary glaucoma. All surgeries were performed using the EyeOP1 device (Eye Tech Care, Rillieux-la-Pape, France). Sixty-six patients were included, and 60 completed regularly the 2-year follow-up. Preoperative IOP was 28.5 ± 9.6 mmHg and significantly decreased to 17.0 ± 5.4 at 2 years (p < 0.001). The daily number of both hypotensive eye drops and acetazolamide tablets decreased significantly (respectively, from 2.6 ± 1.1 to 1.7 ± 1.2 and from 0.7 ± 0.8 to 0.2 ± 0.5; both p < 0.001). At 2 years, 68.1% of patients met the definition of qualified success (IOP < 21 mmHg regardless of glaucoma medications) and 10.3% of patients met the definition of complete success (IOP < 21 mmHg without glaucoma medications). No major intra- or postoperative complications occurred; however, 15 eyes required additional glaucoma surgery. These results suggest that UCP is an effective and safe procedure to reduce IOP in glaucoma patients through a 2-year follow-up period.

Highlights

  • Ultrasound cyclo plasty (UCP) is a recently developed surgical technique for glaucoma allowing a selective and controlled coagulation of the ciliary body

  • 7 patients (10.6%) had a preoperative intraocular pressure (IOP) < 21 mmHg but required surgery because they were intolerant to glaucoma medications

  • The daily number of hypotensive eye drops significantly decreased from 2.6 ± 1.1 at baseline to 1.7 ± 1.2 at the last follow-up (p < 0.001); in parallel, the daily number of 250 mg acetazolamide tablets decreased from 0.7 ± 0.8 to 0.2 ± 0.5 (p < 0.001)

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Summary

Introduction

Ultrasound cyclo plasty (UCP) is a recently developed surgical technique for glaucoma allowing a selective and controlled coagulation of the ciliary body. We investigated the long-term efficacy and safety of UCP for the treatment of glaucoma. This prospective study included patients with primary and secondary glaucoma. No major intra- or postoperative complications occurred; 15 eyes required additional glaucoma surgery. These results suggest that UCP is an effective and safe procedure to reduce IOP in glaucoma patients through a 2-year follow-up period. Ultrasound cyclo plasty (UCP) is a relatively recently developed technique able to achieve a selective and controlled coagulation of the ciliary body by means of high-intensity focused ultrasound while sparing the adjacent ocular s­ tructures[10]. The purpose of this study was to report the 2-year outcomes of UCP procedures performed in 3 Italian glaucoma centers

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