A 2-dose GnRH Agonist trigger maintains supraphysiologic LH levels until the time of oocyte retrieval

Abstract

The use of GnRH agonist (GnRHa) to induce final oocyte maturation in IVF has become increasingly common due to its proven ability to reduce the incidence of OHSS. It has previously been demonstrated that the LH surge induced by a single bolus of GnRHa at mid-cycle results in a shorter LH surge than in natural cycles, with LH levels returning to baseline levels after ∼24 hours (Olivennes, 1996). There has been concern, therefore, that the GnRHa-induced LH surge may not adequately induce maturation and full developmental competence of the oocytes.