Abstract
A 1H-NMR method previously applied to ionophore-mediated transport is used to investigate a similar behaviour by the bile salts. The permeability of phosphatidylcholine vesicles to Pr 3+ is increased by several orders of magnitude over the self-diffusion rate and the kinetics indicate a transbilayer movement of inverted micelles {Pr(bile salt) 4}. In vesicles containing 40 mol% cholesterol the mechanism of permeability is radically altered and the di- and trihydroxy bile salts behave differently.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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