Abstract
Chondroitin sulfates A, B, and C produce well-resolved 13C-n.m.r. spectra which allow for a more complete characterization than that available from their p.m.r. spectra. The 13C data fully support earlier evidence as to the main structural features of these glycosaminoglycans, but they also show that many chondroitin preparations are substantially heterogeneous in composition. Thus, spectra of chondroitin A and C have the appearance of composites representative of both types of polymer: specimens of A may contain 25% of the C-type of structural sequence, and C, 30% of the A-type of sequence; 10–20% of unidentified constituents, including a residue bearing a 6-sulfate group, are present in the specimens of chondroitin B. Chemical-shift and 1 J C-H values found for the L-iduronic acid residues of chondroitin B, as well as the effect of gadolinium nitrate on the relaxation properties of its 13C nuclei, indicate that this moiety possesses the α configuration and favors the 1 C 4(L) conformation. Corresponding data for the acetamidodeoxy- D-galactose and D-glucuronic acid residues of the chondroitins are consistent with the β-anomeric configuration and 4 C 1( D) conformation in all instances.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
