A-105 The Utility of Subjective Reports in Predicting Objective Prospective Memory Outcomes in Amnestic and Non-Amnestic Mild Cognitive Impairment

Abstract

Abstract Objective: Prospective memory (PM) involves remembering to carry out an intended action in the future and is impacted in Mild Cognitive Impairment (MCI) and Alzheimer’s disease (ad). Subjective ratings have been used in reporting patient PM outcomes. This study examined the utility of subjective reports in predicting objective PM in individuals with amnestic mild cognitive impairment (aMCI), non-amnestic mild cognitive impairment (naMCI) and healthy older adults. Methods: Participants included 58 healthy controls (HC), 37 persons with aMCI, and 28 individuals with naMCI. Subjective reports were assessed using caregiver and participant ratings on the Prospective-Retrospective Memory Questionnaire. An objective PM measure was used during the neuropsychological assessment. Simple PM involves remembering to request any pill after a task. Complex PM involves remembering to request the correct number of pills after each task. Results: Linear regression analyses revealed that subjective caregiver and participant ratings predicted simple PM performance for only the HC group, where caregiver reports were unique predictors. Subjective caregiver and participant ratings were not predictive of complex PM performance in any of the groups. Conclusion: Results indicate that subjective caregiver reports were only predictive of healthy participants’ objective simple PM outcomes. This indicates that generally overall subjective ratings are not a substitute for actual PM outcomes in ad and MCI groups. In conclusion, researchers and clinicians should not rely solely on subjective reports in predicting objective outcomes.