A 10-year observational study of Streptococcus dysgalactiae bacteraemia in adults: frequent occurrence among female intravenous drug users.

Corinne Ruppen,Carlo Casanova,Magnus Rasmussen,Parham Sendi

doi:10.4414/smw.2017.14469

Corinne Ruppen, Carlo Casanova + Show 2 more

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https://doi.org/10.4414/smw.2017.14469

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Abstract

Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (43%) and emm types stG62647.0 (26%) were the most frequent clinical manifestation and emm type, respectively. Nineteen (28%) episodes occurred in intravenous drug users (75% women). Our observational study shows similarities to but also differences from other reports. The former include the most frequent clinical presentations, and the most frequently found emm types. This report highlights a relatively high proportion of female intravenous drug users among S. dysgalactiae bacteraemia episodes.

Highlights

Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections
We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015
Nineteen (28%) episodes occurred in intravenous drug users (75% women)

Summary

Introduction

Beta-haemolytic streptococci of groups C and G (GCS and GGS) have become increasingly recognized as causes of invasive human infections [1,2,3]. The vast majority of GGS and GCS belong to Streptococcus dysgalactiae, of which subsp. They cause a spectrum of disease similar to that of Streptococcus pyogenes. Previous publications reported that the most common clinical manifestations of S. dysgalactiae infections include skin and soft-tissue infections, followed by bacteraemia of unknown origin. These infections are often observed in elderly patients and those with underlying medical conditions [1,2,3,4,5,6]. The distribution of S. dysgalactiae emm types was determined

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