Abstract
Herein, we designed the tyrosinase specific sensing probe NITYO with recognition unit, 3-hydroxy benzyloxy, that also regarded as an electron-rich group that quenches the naphthalimide core by PET effect. When tyrosinase exists and catalyzes the secondary oxidation of NITYO, the fluorescence emission goes red shift with “turn-on” signal. We hypothesized and confirmed these results through comprehensive analysis such as molecular orbital analysis, molecular docking and HRMS. To sum up, we achieve the tyrosinase detection by NITYO with highly sensitivity and selectivity. It can be used in food samples and in vivo bioimaging. Besides, NITYO performs superb linear fitting and lower detection limit (0.33 U/mL) within the range of 10–400 U/mL.
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