A-05 The Latin American Spanish Version of the Face-Name Associative Memory Exam is Sensitive to Cognitive and Pathological Changes in Preclinical Autosomal Dominant Alzheimer’s Disease

Abstract

Abstract Objective To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are destined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers. Methods 35 cognitively intact mutation carriers (age range 26–41), 48 matched non-carriers (aged 27 to 44), and 19 symptomatic carriers (13 with subjective cognitive concerns, 6 with mild cognitive impairment [MCI]) completed the LAS-FNAME. A subset of participants (31 carriers [12 symptomatic] and 35 non-carriers) traveled from Colombia to Boston to undergo positron emission tomography (PET) using Pittsburgh compound B to measure mean cortical amyloid-β and Flortaucipir for regional tau tangles. ANOVA analyses and Spearman correlations were used to examine group differences and relationships among LAS-FNAME performance, Aβ and tau accumulation. Results Compared to non-carriers, cognitively intact carriers had lower scores on the LAS-FNAME total scores (p = .040). Across all carriers (including symptomatic carriers), higher levels of amyloid-β (r = −.436, p = .018) and regional tau in the entorhinal (r = −.394, p = .031) and inferior temporal cortex (r = −.563, p = .001) were associated with lower LAS-FNAME total scores (see Figure). Conclusions Performance on the LAS-FNAME differentiated between cognitively intact mutation carriers from non-carriers, and was associated with greater amyloid and tau burden when examining all carriers. Findings suggest that the LAS-FNAME is sensitive to early clinical and pathological changes and can potentially help track disease progression in Spanish-speaking individuals.