9P The role of ICAM1 in glioblastoma tumor associated macrophages under hypoxia

Abstract

Glioblastoma (GBM) is an aggressive and fatal brain cancer in adults with ineffective existing treatment methods. Intracellular adhesion molecule 1 (ICAM1) is a cell adhesion molecule expressed by tumor associated macrophages (TAMs) in GBM. TAMs enhance tumor growth and proliferation, particularly within the characteristic hypoxic tumor microenvironment (TME) of GBM. Hypothesis: I hypothesize that the expression of ICAM1 on the surface of TAMs contributes to GBM cell invasiveness, especially in the hypoxic TME, by enhancing the interaction between tumor cells and macrophages, thereby facilitating the migration, proliferation and invasion of the tumor cells.