Abstract
Complexation of glimepiride with 99mTc, factors affecting yield and suitability of the 99mTc-glimepiride as a tracer for pancreatic β-cells mass were investigated. The radiocomplex showed maximum RCP of 98.2% and remained more than 90% stable up to 8 h in saline and serum. the complex structure and its binding to target sulphonyl urea receptor were assessed in silico. The 99mTc-glimepiride showed saturated in vitro binding with islet cells with a maximum uptake of 73%. Biodistribution and imaging studies suggested the feasibility of the tracer as a good candidate for specifically targeting β-cells mass in humans.
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