Abstract
Exogenous natural surfactant (ENS) labeled with 99mTc ( 99mTc-ENS, 900–1110 MBq), a new radiopharmaceutical for ventilation scintigraphy, was nebulized during 3 min to five volunteers. For comparative purposes, 99mTc-diethylenetriamine pentaacetic acid (DTPA) was studied in the same way. 99mTc-ENS images were of at least the same quality as 99mTc-DTPA images. However, in smoking volunteers, the 99mTc-DTPA images show some areas that seemed to be not well-ventilated, although these areas appeared well-ventilated when the study was performed with 99mTc-ENS. These results suggest that 99mTc-ENS can be used for ventilation scintigraphy to allow the observation of some areas that cannot been visualized using 99mTc-DTPA as ventilation agent.
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