Abstract

The biological behavior of 99mTc-labeled exogenous natural surfactant ( 99mTc-ENS) was studied and compared to 99mTc-diethylenetriaminepentaacetate ( 99mTc-DTPA) and 99mTcO 4 −. The labeling yield percentages for 99mTc-DTPA and 99mTc-ENS were higher than 95%. Biodistribution studies performed after aerosolization showed that the percentage of activity concentration in lungs for 99mTc-ENS was 98.7 ± 1.3%, for 99mTc-DTPA 77.8 ± 20.6%, and 22.4 ± 7.5% in the case of 99mTcO 4 −. These results suggest that this new radiopharmaceutical shows an optimal lung concentration, and therefore it can be considered for clinical trials.

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