Abstract
The plasma binding of Tc-complexes of pyrophosphate, MDP and HMDP was investigated in vitro usinggel chromatography on Biogel P-200. Binding percentages ranging from 5–15% were found. The pH of the preparation of the radio-pharmaceutical had a large effect on the protein binding. The differences between the three ligands used were small. The chemical composition of the complexes was investigated for Tc(Sn)pyrophosphate using gel chromatography on Biogel P-4. The protein-bound technetium was not attached to pyrophosphate. The chemical composition of the unbound Tc-complex is discussed. Finally a comparison is made with literature data. It is concluded that protein binding plays a minorrole.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
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