Abstract
99mTc may be produced from 99Mo/99mTc zirconium molybdate gel generators. These gels are part of the generator matrix and their chemical and physical characteristics directly influence the generator performances. In this work zirconium molybdate gels were synthesized under different preparation conditions and characterized by TGA, IR and INAA. Our goal was to investigate and correlate generator performance with the physical-chemical properties of the gel. The two factors studied were the molybdate solution pH and the preparation conditions of the zirconyl salt solutions. Several polymolybdate and zirconium species can be formed in solution which can inhibit or favor the zirconium molybdate gel formation or the insoluble polymolybdate-rich and zirconium oxy-hydroxide phases. The 99Mo/99mTc gel generator performance is directly correlated with gel structures. More regular network gels present lower generator performances compared to gels with more flexible random framework. The physico-chemical properties of the gels as well as their behavior as technetium-99m generators are presented and discussed.
Highlights
99mTc is widely used as diagnostic agent in nuclear medicine and is generally produced by generator systems, where the 99Mo is normally adsorbed onto an alumina column
We have studied the pH of molybdate solutions and the preparation conditions of zirconyl salt solutions used to synthesize the zirconium molybdate gels and its effect on generator performances and on the physico-chemical properties of the gel
As for the gels prepared with zirconyl solutions at different ageing times, the highest elution volume (4.1- 4.3 mL) was obtained in the prepared gel with 0.1 mol L-1 ZrOCl2.8H2O solution aged for 1 h, this gel presented the narrowest elution profile
Summary
99mTc is widely used as diagnostic agent in nuclear medicine and is generally produced by generator systems, where the 99Mo is normally adsorbed onto an alumina column. The order of reactive addition, the drying temperature of the final product, etc., must be carefully studied and determined to reproduce the properties of the gel generators.[2,9] In order to find alternatives of 99mTc generator production, efficient and easy to manufacture, our laboratory has developed and evaluated the zirconium molybdate gel and its effect on generator performances.[9,10] In this work, we have studied the pH of molybdate solutions and the preparation conditions of zirconyl salt solutions used to synthesize the zirconium molybdate gels and its effect on generator performances and on the physico-chemical properties of the gel These factors have previously only been studied by Evans and Shying,[2] who detected a decrease on the generator efficiency as the pH of molybdate solutions diminish and when the pH of zirconium oxynitrate solutions is less 0.95. The gel concentrations of zirconium and molybdenum were determined by means of neutron activation analysis (NAA).[8]
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