99Mo/99mTc generators based on aluminum molybdate gel matrix prepared by nano method

Abstract

A procedure for preparation of 99Mo/99mTc radioisotope generator based on low specific activity neutron activated 99Mo was developed. Aluminum molybdate(VI)-99Mo of high Mo(VI) content (~ 364 mg/g Al99Mo) was prepared by mixing low specific activity molybdate(VI)-99Mo and aluminum mixture solution with isoamyl alcohol. Al99Mo gel matrix was precipitated when the pH of the mixture solution was raised to ~ 5 by addition of NaOH to the mixture. Radiometric measurements indicate the strong fixation of Molybdate(VI)-99Mo species in the form of the sparingly insoluble Al99Mo gel matrix. The prepared AlMo gel matrix was physiochemically characterized. Al99Mo gel matrix was used as a base material for preparation of 99Mo/99mTc generator. The 99mTc eluted from 99Mo/99mTc radioisotope generator was found to have relatively high elution yield (84 ± 2.3%), radionuclidic (≥ 99.99%), radiochemical (98.1 ± 0.9%) and chemical purity.