Abstract
The development of nanoparticle-based dual-modality probes for magnetic resonance imaging (MRI) and positron emission tomography (PET) or single photon emission computed tomography (SPECT) is increasingly growing in importance. One of the most commonly used radionuclides for clinical SPECT imaging is (99m)Tc and the labelling of Fe3O4 nanoparticles with (99m)Tc was shown to be a successful strategy to obtain dual-modality imaging agents. In this work, we focus on gold containing magnetic nanomaterials. The radiolabelling of magnetic Fe3O4-Au core-shell and Fe3O4-Au dumbbell-like nanoparticles with the [(99m)Tc(CO)3](+) fragment is described. The key elements for this (99m)Tc labelling approach are novel coating ligands, consisting of an anchor for the Au surface, a polyethylene glycol linker and a strong chelator for the [(99m)Tc(CO)3](+) moiety.
Highlights
Over the last decade, magnetic nanomaterials (MNs) have gained a lot of interest in the field of biomedical applications, including imaging, drug delivery, protein purification, and therapy.[1,2,3,4] The most commonly used MNs are iron oxide nanoparticles (IONPs), especially as magnetic resonance imaging (MRI) contrast agents for T2-weighted acquisitions.[5]
Several research groups brought the combination of IONPs with a radiolabel for positron emission tomography (PET) or single photon emission computed tomography (SPECT) into focus
We focused our attention on these nanocomposites due to recent reports showing that the degradation products of IONPs increase free radical production in physiological environments which might lead to cell death.[20]
Summary
Magnetic nanomaterials (MNs) have gained a lot of interest in the field of biomedical applications, including imaging, drug delivery, protein purification, and therapy.[1,2,3,4] The most commonly used MNs are iron oxide nanoparticles (IONPs), especially as magnetic resonance imaging (MRI) contrast agents for T2-weighted acquisitions.[5]. We aimed at labelling magnetic Fe3O4–Au core– shell and Au–Fe3O4 dumbbell-like nanoparticles (NPs) with the [99mTc(CO)3]+ moiety.
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