999 LONG-TERM ONCOLOGICAL OUTCOME FOLLOWING LAPAROSCOPIC RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Localized (IV)1 Apr 2013999 LONG-TERM ONCOLOGICAL OUTCOME FOLLOWING LAPAROSCOPIC RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER Ashkan Mortezavi, Jacopo Robbiani, Martin Baumgartner, Daniel Eberli, Peter Wild, Hans-Helge Seifert, Tullio Sulser, and Thomas Hermanns Ashkan MortezaviAshkan Mortezavi Z rich, Switzerland More articles by this author , Jacopo RobbianiJacopo Robbiani Z rich, Switzerland More articles by this author , Martin BaumgartnerMartin Baumgartner Z rich, Switzerland More articles by this author , Daniel EberliDaniel Eberli Z rich, Switzerland More articles by this author , Peter WildPeter Wild Z rich, Switzerland More articles by this author , Hans-Helge SeifertHans-Helge Seifert Z rich, Switzerland More articles by this author , Tullio SulserTullio Sulser Z rich, Switzerland More articles by this author , and Thomas HermannsThomas Hermanns Z rich, Switzerland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.583AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES When laparoscopic radical prostatectomy (LRP) was introduced as a new technique, it had to compete with open retropubic radical prostatectomy (RRP) as the gold standard surgical therapy for localized prostate cancer. Although the operation time was longer, the intra- and postoperative results of the new technique were promising with lower perioperative morbidity and less blood loss. Short-term and intermediate-term oncological and functional outcome have been reported to be encouraging and comparable to the open technique. However, true long-term oncological outcome for LRP is still only sparsely available. We evaluated the long-term oncological outcome of an initial series of LRP. METHODS Between July 1999 and October 2001 a total of 100 consecutive patients with clinically localized prostate cancer underwent LRP performed by a single surgeon. Pre-, intra- and postoperative data were collected. Post-operatively, all patients were routinely assessed using a PSA-test after 6 weeks, 3, 6 and 12 months, and yearly thereafter. Cancer control was defined as sustained PSA level of <0.2 ng/mL. RESULTS The mean patients' age was 64 years (±7y SD) and the mean preoperative PSA value 9.6 (±8.3) ng/mL. Pathology of the specimen revealed, that 79 of the patients (79%) had a pT2 tumour and 15 patients (15%) a pT3 tumour. The specimen Gleason score was 4-6 in 54 patients (54%), 7 in 32 patients (32%) and 8-10 in 14 patients (14%), respectively. The total rate of positive surgical margins was 25% (16.5% for pT2 and 40% for pT3). The median follow-up time was 107 months (range 60-139). The 2, 5 and 10-year CC rates were 87%, 82% and 78%, respectively. For patients with pT2 or pT3 disease these rates were 90%, 85% and 81% or 87%, 80% and 80%, respectively. The 10 years tumour specific survival rate was 99%. CONCLUSIONS LRP effectively controlled the disease in 78% of men with prostate cancer after 10 years. Although these results are from a very initial series, oncologic results after a follow-up of up to 139 months are comparable to other representative series of RRP. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e410 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ashkan Mortezavi Z rich, Switzerland More articles by this author Jacopo Robbiani Z rich, Switzerland More articles by this author Martin Baumgartner Z rich, Switzerland More articles by this author Daniel Eberli Z rich, Switzerland More articles by this author Peter Wild Z rich, Switzerland More articles by this author Hans-Helge Seifert Z rich, Switzerland More articles by this author Tullio Sulser Z rich, Switzerland More articles by this author Thomas Hermanns Z rich, Switzerland More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...