997 IMPACT OF SURGERY DELAY IN PATIENTS DIAGNOSED WITH HIGH GRADE PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Localized (IV)1 Apr 2013997 IMPACT OF SURGERY DELAY IN PATIENTS DIAGNOSED WITH HIGH GRADE PROSTATE CANCER Srinivas Samavedi, Haidar Abdul-Muhsin, Oscar Schatloff, Kenneth Palmer, George Ebra, and Vipul Patel Srinivas SamavediSrinivas Samavedi Celebration, FL More articles by this author , Haidar Abdul-MuhsinHaidar Abdul-Muhsin Celebration, FL More articles by this author , Oscar SchatloffOscar Schatloff Celebration, FL More articles by this author , Kenneth PalmerKenneth Palmer Celebration, FL More articles by this author , George EbraGeorge Ebra Celebration, FL More articles by this author , and Vipul PatelVipul Patel Celebration, FL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.581AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Controversy continues to exist concerning the impact of surgical delay following prostate biopsy on outcomes after robotic assisted radical prostatectomy (RARP). The purpose of this investigation is to evaluate the impact of surgical delay following biopsy in patients diagnosed with high-risk prostate cancer. METHODS From January 2008 through December 2011, a total of 2858 patients underwent RARP by a single surgeon (VP). There were 26 patients who underwent a salvage procedure and were excluded from the study cohort. The resulting study population (N=2832) was stratified into 3 groups according to the time interval between biopsy and RARP: Group I (n=1101) ≤ 3 months, Group II (n=1448) 3 to 6 months, and Group III (n=283) 6 to 12 months. The distribution of demographic, clinical, pre- and post-operative pathological outcomes as well as upgrading was compared among the groups using ANOVA for continuous variables and Chi-square for categorical variables. RESULTS Groups were comparable in age, body mass index, PSA score and clinical T stage. Differences were observed in D'Amico risk classification, Gleason biopsy score sum and the number of positive biopsy cores (p<0.001). Postoperatively, the 3 groups stratified by D'Amico risk classification, had similar incidence of positive lymph nodes, positive surgical margins, lymphovascular invasion and seminal vesicle invasion. A significant difference (p<0.040) was observed in tumor volume in intermediate risk patients and for perineural invasion (p=0.030) in high risk patients. No significant differences were observed in tumor upgrading or pathological stage distribution among the groups. CONCLUSIONS Postoperative pathological findings were consistent among all risk categories with the exception of tumor volume and perineural invasion. Comparable pathological outcomes were observed for high risk patients across all time intervals. This study demonstrates that a 12 month delay in RARP after prostate biopsy does not adversely affect oncological outcomes. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e409 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Srinivas Samavedi Celebration, FL More articles by this author Haidar Abdul-Muhsin Celebration, FL More articles by this author Oscar Schatloff Celebration, FL More articles by this author Kenneth Palmer Celebration, FL More articles by this author George Ebra Celebration, FL More articles by this author Vipul Patel Celebration, FL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...