994 STANDARDIZED RELATIVE SURVIVAL AND MORTALITY AFTER RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Localized (IV)1 Apr 2013994 STANDARDIZED RELATIVE SURVIVAL AND MORTALITY AFTER RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER M. Andreas Røder, Kasper D. Berg, Frederik B. Thomsen, Lisa Gruschy, Ea Rusch, Klaus Brasso, and Peter Iversen M. Andreas RøderM. Andreas Røder Copenhagen, Denmark More articles by this author , Kasper D. BergKasper D. Berg Copenhagen, Denmark More articles by this author , Frederik B. ThomsenFrederik B. Thomsen Copenhagen, Denmark More articles by this author , Lisa GruschyLisa Gruschy Copenhagen, Denmark More articles by this author , Ea RuschEa Rusch Copenhagen, Denmark More articles by this author , Klaus BrassoKlaus Brasso Copenhagen, Denmark More articles by this author , and Peter IversenPeter Iversen Copenhagen, Denmark More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.578AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Survival remains the most valuable endpoint for description of efficacy after radical prostatectomy (RP) for prostate cancer (PCa). Survival is typically reported as overall and cancer-specific. The objective of this study was to investigate standardised relative survival and mortality ratio in patients undergoing RP for localized PCa at our institution during the past 15 years. METHODS Between 1995-2010, 1350 consecutive patients underwent RP for clinically localized PCa. Patients have been followed prospectively per protocol. No patients were lost to follow-up. Overall and cause-specific survival was described using Kaplan-Meier estimation. Standardized relative survival and mortality ratio was calculated based on expected survival in the age-matched Danish population using the methods and macros described by Dickmann. The country-specific population mortality rates used for calculating the expected survival were based on the data from The Human Mortality Database. Standadized mortality was calculated as observed mortality in the cohort / expected mortality in Denmark. RESULTS Median follow-up was 3.4 years (range: 0-14.3 years). Fifty-nine (4.4%) patients died during follow-up. Seven-teen (1.3%) patients died of PCa. Estimated ten-year overall survival was 89.3%. Cancer-specific survival was estimated to 96.6% after 10 years. Relative survival following 5 and 10 years was 1.04 and 1.14. Standardized mortality ratio was 0.61 and 0.39 at 5- and 10 years. CONCLUSIONS Overall and cancer-specific survival in a consecutive series of patients in a non-screened Danish population after ten years is >90%. Survival and mortality ratio is significantly better than expected in the age-matched background population. This finding is likely explained by selection bias. Although the results indicate an excellent outcome in terms of cancer control the efficacy of prostatectomy as treatment of localized PCa remains at debate. Patient characteristics and survival/mortality data Median Range Age 63 45-76 PSA, ng/ml 8.7 0.1-2011 N cT category T1 683 50.6 T2 629 46.6 T3 28 2.8 Biopsy Gleason score ≤ 6 635 47 7 529 39.2 ≥ 8 63 4.7 N/A 123 9.1 Standardized relative survival (95% CI) at 1 year 1.015 (1.010-1.016) at 5 years 1.038 (1.011-1.057) at 10 years 1.137 (1.045-1.186) Standardized mortality ratio (95% CI) at 1 year 0.100 (0.025-0.403) at 5 years 0.607 (0.419-0.879) at 10 years 0.393 (0.197-0.787) © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e408 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information M. Andreas Røder Copenhagen, Denmark More articles by this author Kasper D. Berg Copenhagen, Denmark More articles by this author Frederik B. Thomsen Copenhagen, Denmark More articles by this author Lisa Gruschy Copenhagen, Denmark More articles by this author Ea Rusch Copenhagen, Denmark More articles by this author Klaus Brasso Copenhagen, Denmark More articles by this author Peter Iversen Copenhagen, Denmark More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...