991 High-Resolution Esophageal Manometry Identifies Important Esophageal Motor Dysfunction in Lung Transplant Candidates

Abstract

pressure volume measurement tool, and ratios of 3rd segment to 2nd segment calculated. Values were compared to a cohort of healthy normal controls (n=14, age 35.4 ±1.8, 7F/ 7M). RESULTS: The 2nd peristaltic segment length was similar in the three groups, but the 3rd segment was shorter in the GERD group compared to the other two groups (p≤0.001). A visually conspicuous and distinctive shift in peak contraction amplitude to the 3rd contraction segment was evident in the acid sensitivity group (2nd segment, 100.03±11.06 mmHg, 3rd segment 145.23±10.29 mmHg, p=0.006), a finding not seen in the GERD (2nd segment, 96.26±9.42 mmHg, 3rd segment 96.43±10.89 mmHg, p=ns) and control groups (2nd segment, 104.84±9.57 mmHg, 3rd segment 113.59±9.01 mmHg, p=ns). Further, pressure volumes were similarly shifted to the 3rd segment in the acid sensitivity group (2nd segment: 855.3±135.1 mmHg/cm/sec, 3rd segment: 2115.2±218.6 mmHg/cm/sec, p<0.005), and a threshold 3rd segment: 2nd segment pressure volume ratio of 2:1 segregated 88% of acid sensitivity subjects from GERD subjects. CONCLUSIONS: Characteristics of smooth muscle contraction segments on HRM can distinguish acid sensitivity from GERD in NCCP. 3rd:2nd Segment Ratio Comparison