Abstract
Introduction: Comparison of subcutaneous and transvenous implantable cardioverter-defibrillator (S-ICD, TV-ICD) therapy in previous studies is hampered by dissimilar patient characteristics. This study compared long-term clinical outcomes of both ICDs in a balanced cohort. Methods: ICD patients from two tertiary centers in The Netherlands were compared; S-ICDs implanted since 2009 (n = 140) and TV-ICDs between 2005-2014 (n = 1014). S-ICD patients were 1:1 propensity matched to 140 TV-ICD patients for 16 baseline characteristics including diagnosis. Kaplan Meier estimates for complications requiring surgical intervention were calculated at 5-year follow-up and hazard ratios (HR) for appropriate and inappropriate therapy adjusted for ICD settings. Conclusion: Long-term outcomes in this balanced cohort of S-ICDs and TV-ICDs were equal for complications and shocks. Patients with TV-ICDs had more appropriate interventions and lead complications, but S-ICD patients had more non-lead complications.
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