989 A NOVEL METHOD FOR REAL-TIME PROSTATE TISSUE CHARACTERIZATION

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening1 Apr 2011989 A NOVEL METHOD FOR REAL-TIME PROSTATE TISSUE CHARACTERIZATION Zohar Dotan, Eddie Fridman, Arie Lindner, Jacob Ramon, Dov Pode, Jacob Bejar, Juri Kopolovic, Galina Pizov, Judith Sandbank, Ran Katz, Amos Shapiro, Yaniv Shilo, and Ofer Nativ Zohar DotanZohar Dotan Ramat Gan, Israel More articles by this author , Eddie FridmanEddie Fridman Ramat Gan, Israel More articles by this author , Arie LindnerArie Lindner Zrifin, Israel More articles by this author , Jacob RamonJacob Ramon Ramat Gan, Israel More articles by this author , Dov PodeDov Pode Jerusalem, Israel More articles by this author , Jacob BejarJacob Bejar Haifa, Israel More articles by this author , Juri KopolovicJuri Kopolovic Haifa, Israel More articles by this author , Galina PizovGalina Pizov Jerusalem, Israel More articles by this author , Judith SandbankJudith Sandbank Zrifin, Israel More articles by this author , Ran KatzRan Katz Jerusalem, Israel More articles by this author , Amos ShapiroAmos Shapiro Jerusalem, Israel More articles by this author , Yaniv ShiloYaniv Shilo Zrifin, Israel More articles by this author , and Ofer NativOfer Nativ Haifa, Israel More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1021AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of radical prostatectomy (RP) is completely removing the prostate gland with negative surgical margins. The presence of cancer at the surgical margin is associated with higher probability of disease progression. Current methods of intra-operative margin assessment are inaccurate or time-consuming. The study goal was to evaluate the ability of a novel device (Dune Medical Devices) in differentiating between cancer and benign prostatic tissue. METHODS Between November 2007 and May 2008, 49 patients undergoing RP were enrolled in this study in 4 medical centers. The device was applied to numerous intra- and extra-capsular sites of freshly excised RP specimens. Measurement sites were accurately marked and analyzed histologically. The ability of the device to differentiate between malignant and non-malignant sites was assessed. RESULTS A total of 15,156 measurements from 45 patients were analyzed. Differentiation of the intra-capsular malignant sites from extra-capsular non-malignant sites (bladder neck and apex regions), depends on the cancer feature size. The differentiation was achieved with sensitivity and specificity of 93.6 (95% CI: 88–98) and 94.1 (95% CI: 93–95) respectively, at feature sizes at or above 0.8mm in diameter. The device ability to discriminate between all intra-capsular malignant and non-malignant measurement sites in terms of sensitivity and specificity are 80.8 (95% CI: 73–87) and 68.4 (95% CI: 67–69), respectively. CONCLUSIONS Radio-Frequency near-field spectroscopy sensor can differentiate efficaciously between cancer and benign prostate tissue. The sensor's dimensions and design should enable use in open, laparoscopic, and robotic RP in order to evaluate the surgical margins intraoperatively. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e399 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zohar Dotan Ramat Gan, Israel More articles by this author Eddie Fridman Ramat Gan, Israel More articles by this author Arie Lindner Zrifin, Israel More articles by this author Jacob Ramon Ramat Gan, Israel More articles by this author Dov Pode Jerusalem, Israel More articles by this author Jacob Bejar Haifa, Israel More articles by this author Juri Kopolovic Haifa, Israel More articles by this author Galina Pizov Jerusalem, Israel More articles by this author Judith Sandbank Zrifin, Israel More articles by this author Ran Katz Jerusalem, Israel More articles by this author Amos Shapiro Jerusalem, Israel More articles by this author Yaniv Shilo Zrifin, Israel More articles by this author Ofer Nativ Haifa, Israel More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...