Abstract
The presence of intercellular adhesion molecule-1 (ICAM-1) on arterial endothelial cells and on non-endothelial cells has previously demonstrated in human coronary atherosclerotic plaques. We hypothesized that ICAM-1 expression on coronary arteries is increased by mechanical compression of coronary atherosclerotic plaques such as coronary balloon angioplasty. Coronary thrombolysis (intravenous administration of alteplase. 0.45 mg/kg) was done in 31 consecutive patients with acute myocardial infarction (AMI) immediately after admission. Thirteen patients whose coronary arteries were not recanalized completely (below TIMI grade 2) were performed subsequent coronary angioplasty. Blood sampling were done on admission, 2, 4, 8, 12, 24,48, 72 and 96 hours after admission. Plasma levels of soluble ICAM-1 were measured by enzyme-linked immunosorbent assay. Plasma soluble ICAM-1 level was increased significantly in patients with angioplasty (p = 0.03. vs patients without angioplasty) and the level reached a peak 8 hours after admission (116 ± 7% of baseline level). On the other hand. the level was unchanged in patients without angioplasty (99 ± 3% of baseline. 8 hours after admission).Download : Download high-res image (92KB)Download : Download full-size image Plasma levels of soluble ICAM-1 are increased after angioplasty in patients with AMI. Mechanical stimulation of coronary atherosclerotic plaques by balloon catheter may induce activation of mononuclear leukocyte or T-lymphocyte in the vessel wall. Cytokines released from the activated leukocyte may amplify the synthesis of ICAM-1 on the endothelium and increase the plasma level of ICAM-1.
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