Abstract
Foamy virus (FV) vectors have been demonstrated to transduce human hematopoietic stem cells with a high frequency. We have developed FV vectors that can block HIV infection with the intention of developing a therapeutic vector. Additional features of FV vectors that support their use in clinical gene therapy include: a) no evidence of disease from the prototypic FV in infected humans and in non-human primates, b) reduced recombination potential with HIV in infected patients, c) FV vectors are self-inactivating vectors, and d) relative to lentivirus vectors, FV vector production does not share molecular pathways with HIV.
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