Abstract
Local infusion of angiopeptin (AP) into injured swine coronary arteries using the porous balloon has been shown to reduce neointima. The purpose of this study was to compare prolonged (20 min) infusion of low dose AP (20 μg/kg) with a short (3 min) infusion of high dose AP (500 μg/kg) using the DispatchTM device which allows atraumatic and extended drug/arterial wall contact. 21 swine underwent overstretch balloon injury to the coronary arteries. AP was infused at either low or high dose immediately post-injury. Vessels were harvested at 14 days and the neointimal area (NEG), % neointima (NEO/Wall Area), % internal elastic lamina fracture (IEL break/IEL length) and residual lumen (lumen area/Iumen area + intimal area) were determined.Download : Download high-res image (62KB)Download : Download full-size image Prolonged low dose local infusion of AP at the injury site reduced the neointima and improved the residual lumen in the treated vessel. The beneficial effect of AP was not demonstrated with the higher dose, shorter duration local infusion.
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