983 MATERNAL HISTORY OF HYPERTENSION PREDICTS BLOOD PRESSURE RESPONSE TO POTASSIUM INTAKE

Abstract

Objective: To examine the relationship between parental history of hypertension and blood pressure responses to dietary potassium. Methods: We conducted a dietary-feeding study that included a 7-day high-sodium followed by a 7-day high-sodium plus potassium intervention among 1,871 Chinese participants. Blood pressure was measured on the last 3 days of each intervention phase. Parental hypertension status was ascertained during a baseline examination. Results: Those with a maternal history of hypertension had larger multivariable-adjusted systolic blood pressure responses (95% confidence interval) to potassium intake compared to those with no maternal history: -4.33 (-5.08, -3.57) versus -3.36 (-4.11, -2.62) mmHg, respectively (p-value = 0.003). A consistent trend was observed for diastolic blood pressure responses: -1.81 (-2.45, -1.17) versus -1.35 (-1.98, -0.72), respectively (p-value = 0.08). We noted a stronger association between early-onset maternal hypertension (diagnosed before age 65) and blood pressure responses. Participants with a history of early-onset maternal hypertension compared to those without had systolic blood pressure decreases of -4.74 (-5.64, -3.84) versus -3.54 (-4.26, -2.83) mmHg, respectively (p-value = 0.002) and diastolic blood pressure decreases of -2.25 (-3.01, -1.48) versus -1.38 (-1.99, -0.77) mmHg, respectively (p-value = 0.006). Odds ratios (95% confidence intervals) for high potassium-sensitivity were 1.36 (0.96, 1.93) and 1.62 (1.10, 2.39) for those with a maternal history of hypertension and early-onset hypertension, respectively (p-values = 0.08 and 0.01, respectively). Paternal hypertension was not associated with potassium-sensitivity. Conclusions: Maternal history of hypertension strongly predicted blood pressure responses to potassium intake. Potassium supplementation could be a particularly important strategy for blood pressure reduction among this subgroup of individuals.